Equipment

• Biacore T200 (Cytiva).

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• Beckman Coulter MoFlo Astrios separator cytometer, 4 lasers, 14 colors.
• Becton Dickinson FACSCanto II analyser cytometer, 2 lasers, 6 colors.
• FACScalibur analyser cytometer, 2 lasers, 4 colors.
• Beckman Coulter Gallios analyser cytometer, 3 lasers, 10 colours.
• Fluostar optima microplate reader (bmg) with double injection system and temperature regulator.
• Odyssey^® M fluorescence image scanner (Li-cor).

• Mass cytometer (Cytof) Helios (Fluidigm).
• Discover S8^TM (Becton Dikinson) cell sorter with flow hood, 5 lasers, spectral.
• Aria FUSION (Becton Dikinson) cell sorter (2 equipments), with flow hood, 4 lasers, 16 colors.
• Aria SORP (Becton Dikinson) cell sorter, 4 lasers, 18 colors.
• Gallios (Beckman Coulter) flow cytometer, 3 lasers, 10 colors.
• Aurora (Cytek) flow cytometer, 4 lasers, spectral.
• Cytometer analyzer Symphony A3 (Becton dickinson), 5 lasers, 28 colors.
• Magpix (Luminex)for soluble antigens detection.

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• Spirit TWIN (FEI) 120 kV LaB6 Tecnai TEM cryomicroscope with Megaview 1kx1k CCD and tomograph.
• Tecnai G2 F20 (FEI) 200 kV FEG TEM cryomicroscope with Eagle 4kx4k CCD and tomograph.
• Jeol JEM 1010 100 kV TEM microscope with Megaview 1kx1k CCD.
• Leica DM2000LED fluorescence microscope.
• Leica UC6/FC6 cryoultramicrotome with cryosphere.
• Leica UCT ultramicrotome.
• Ultracut E ultramicrotome.
• Leica UC7/FC7 cryoultramicrotome.
• Vitrobot Mark III (FEI) immersion cryofixation/vitrification .
• Leica AFS cryosubstitution (2).
• Leica EM-AFS2 freeze substitution.
• Baltec 060 BAF cryofracture/freeze-etching.
• In situ laboratory: paraffin microtome, optical microscope and accessories.
• Leica EM HPM100 high-pressure freezing.
• Leica EM-ACE 600 high-vacuum carbon coater.
• Modular Stereomicroscope Leica MZ6 with SFL 100 (fluorescence module).
• Eppendorf 5804R refrigerated centrifuge.

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• Cages and stable stalls.
• Glass aquaria and polyester tanks.
• Biological safety cabinets.
• Extractor hoods.
• Centrifuges.
• Experimental operating room.
• Surgical magnifying glasses.
• Ventilators for assisted breathing.
• Gas anaesthesia equipment.
• Perkin Elmer In vivo IVIS-Lumina III Bioluminescence and Fluorescence equipment.
• Hamamatsu Aequoria Bioluminescence and Fluorescence equipment.
• Rodent stabling under conventional conditions.
• Rodent stabling under SPF conditions.
• Rodent stabling under negative pressure conditions.
• Rabbit stabling under conventional conditions.
• Pig stabling under conventional conditions.
• Experimental labs in the conventional zone.
• Experimental labs in the SPF zone.
• Behavior labs in the conventional zone.
• Behavior labs in the SPF zone.
• Ventilated racks.
• Filter cages.
• Metabolic cages.
• Confocal Laser Scanning Microscope and Multiphoton with Resonant Scanner. With temperature control.
• 7T Experimental Magnetic Resonance imaging equipment.
• Biological irradiator.
• Software with tracking system SMART 3.0.
• Thermal blankets.
• Triple beam balance.
• Precision balance.
• Hydrogen peroxide SAS.
• UV SAS.
• Air shower.
• ISO 9001:2015 quality management system.
• AniBio, Unit management software.

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• Applied Biosystems ABI Prism 7900 HT quantitative real-time PCR.
• Applied Biosystems QuantStudio 7 pro quantitative real-time PCR.
• Chemagen Magnetic nucleic acid isolation module.
• Agilent Technologies Bioanalyzer 2100.
• BMG Labtech Fluostar Optima Microplate reader with double injection system and temperature control.

• Applied Biosystems ABI Prism 3730 capillary electrophoresis DNA sequencer (48 capillary).
• Applied Biosystems ABI Prism 3730XL capillary electrophoresis DNA sequencer (96 capillary).
• Applied Biosystems ABI Prism 7900 HT quantitative real-time PCR.
• Roche Light Cycler 480 II quantitative real-time PCR.
• Applied Biosystems QuantStudio 7 pro quantitative real-time PCR.
• Agilent Technologies Bioanalyzer 2100.
• Applied Biosystems thermocyclers: PCR ABI 9700, PCR ABI 9800 Fast, PCR ABI 2400 and 2720; MGW Biotech PCR Primus thermocycler; Techne PCR TC-412 thermocycler.
• Beckman Coulter Biomeck NXP robotic workstation.
• Qiagen Mixer Mill MM 300 for grinding and homogenizing samples .

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• Transmission electron microscope JEOL 1010 + Orius (Gatan) CCD camera.
• Ultracut E ultramicrotome.
• Reichert-Jung Ultracut ultramicrotome.
• Leica UC7 ultramicrotome with digital IC90-E camera.

• Scanning electron microscope JEOL JSM-7001F with secondary and retro-dispersed electron detectors.
• Polaron Critical Point Drying and and Emitech Critical Point Drying.
• Fisons Coating System SEM.
• Q150Tplus (Quorum) carbon evaporator.

• MIKRO 200R (Hettich) refrigerated centrifuge.
• 13/13 Dr Autocal (Roebling) osmometer.
• pH-2001 (Crison) pH-meter.
• OLYMPUS CX41RF optical microscope with OLYMPUS DP70 digital camera.
• MOTIC BA410E optical microscope with 3+ Moticam digital camera.
• SCZ-T4P Leica binocular magnifier.
• SMZ745T Nikon binocular magnifier.

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• Culture room.
• Fiji, Image J, MetaMorph, Imaris and Huygens image treatment workstations.

• Axio Imager M2 Apotome 3 fluorescence microscope.
• Carl Zeiss SteREO Lumar V12 stereo fluorescence microscope.
• Leica DMIRB Microscope.
• Leica TCS-SL confocal microscope with spectral detection.
• Nikon E800 Microscope.
• Zeiss LSM880 high speed spectral confocal microscope.
• Odyssey^® M fluorescence image scanner (Li-cor).

• Bio rad gene gun
• Leica TCS-SP5 high speed, multiphoton, spectral confocal microscope.
• Leica DMI6000 B wide-field fluorescence microscope.
• Leica ASTP microinjector.
• Leica MZFL III stereoscope (color camera).
• Leica DMRB widefield microscope (color camera).
• Olympus BX51 widefield microscope (color Ccmera).
• Zeiss LSM880 high speed spectral confocal microscope.
• Opera Phenix^TM High-Content Screening microscope.

• Leica CM3050S cryostat
• Leica DMIRB wide-field transmitted light and fluorescence microscope.
• Leica MLZIII stereo fluorescence microscope.
• Leica RM 2135 microtome
• Leica SPII confocal microscope with spectral detection.
• Leica TCS-SPE spectral confocal microscope.
• Leica Thunder high-speed fluorescence microscope.
• Zeiss LSM880 high speed spectral confocal microscope.
• Ted-Pella XH-4002 paraffin dispenser.

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• Amersham Biosciences IPGphor 2-D electrophoresis protein separation system and Bio-Rad PROTEAN-IEF

• Amersham Biosciences DeCyder DIGE enabled TYPHOON TRIO fluorescent scanner.

• Genomic Solutions Investigator ProGest digestion unit (up to 96 samples).

• LTQ-Orbitrap Velos ion trap mass spectrometer with Thermo Finnigan electron transfer dissociation (ETD) accessory.
• Thermo Finnigan LCQ DECA XP ESI ion trap.
• Applied Biosystems MALDI-TOF Voyager DE perspective mass spectrometer.
• Proxeon Nano LC Easy and Eksigent Nano LC Ultra AS2 nano liquid chromatographs.

• Licences for Protein Prospector, SEQUEST and Proteome Discoverer 1.2 from Thermo Finnigan , and PEAKS from BioInformatics Solutions.

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• Atomic force microscopes (AFM):
• Bruker Multimode 8 with Nanoscope V controller electronics.
• Bruker Dimension 3100 with Nanoscope IV controller electronics.

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• ESFOSCAN (Photoelectron spectroscope with scanning PHI VersaProbe 4)

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• PANalytical X’Pert PRO MRD diffractometer; high-resolution texture goniometer; parallel and mono-capillary optics; Bartels monochromator; PIXcel detector .
• PANalytical X’Pert PRO MPD theta/theta diffractometer; reflection and transmission configurations; 45-position sample loader; Oxford Cryosystems 700 Cryostream series cryostat; PIXcel detector.
• PANalytical X’Pert PRO MPD alpha1 diffractometer; focusing primary monochromator; 15-position sample loader; X’Celerator detector.
• PANalytical X’Pert PRO MPD theta/theta diffractometer; Bragg-Bentano configuration; A PAAR HTK1200 high-temperature chamber; X’Celerator detector.
• INEL CPS-120 diffractometer; 120º curved position detector; primary monochromator and parabolic mirror; FURCAP INEL temperature chamber .
• Siemens D-500 diffractometers; grazing incidence and divergent optics; A PAAR TTK temperature chamber; scintillation detectors; Braun PSD position detector.
• X-ray single crystal diffractometer Bruker D8 Venture. Cu and Mo microbeam sources. 4 circles Kappa goniometer. Integrated CCD video microscope. CMOS area detector Photon 100. Bruker Kryoflex II cryostat (80 - 400 K)
• XRDynamic 500 multipurpose X-ray diffractometer.

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• Beckman Coulter LS 13 320 laser-diffraction particle dimension analyser.

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• JEOL JEM JEM-ARM200F 'NEOARM' transmission electron microscope
• JEOL JEM 2100 transmission electron microscope with accessories for EDX analysis, STEM annular dark field, precession and tomographic detectors.
• Philips CM30 300 kV transmission electron microscope.
• Hitachi 800MT electron microscope with Gatan multiscan chamber .
• JEOL JEM 2010F 200 kV transmission electron microscope with field emission tube with electron energy loss spectrometer (EELS) and image filter (GIF) and Z-STEM unit with high-angle annular detector.

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• Atomic force microscopy (AFM):
• Bruker Multimode 8 with Nanoscope V controller electronics.
• Bruker Dimension 3100 with Nanoscope IV controller electronics.
• Leica DCM3D interferometric / confocal microscope.

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• Quanta 200 FEI, XTE 325/D8395 environmental scanning electron microscope.
• Jeol J-6510 scanning electron microscope (Freezing unit, GATAN ALTO-1000, EDS detector, backscattered electrons detector).
• JEDL J-7100 field emission scanning electron microscope (Cathodeluminiscence spectrometer GATAN MONO-CL4, EDS detector, retroscattered electron detector).

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• JEOL JXA-8230 microprobe (five WDS spectrometers, one EDS and one soft X-ray emission spectrometer).

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• 2G Enterprises 2G SRM755R superconducting rock magnetometer.
• ASC IM10-30 impulse magnetizer.
• Geofyzica Brno KLY-2 magnetic susceptibilimeter.
• JR6A (Agico) spinner magnetometer.
• Magnetic Measurements Ltd. MMDT80 thermal demagnetizer.
• MFK2 Kappabridge with a CS4 temperature unit and a CS-L cryostat (AGICO).
• Schonstedt Instruments TSD1 thermal demagnetizer.
• Schonstedt Instruments GSD-5 alternating field demagnetizer.
• TD48EU (ASC Scientific) thermal demagnetizer.

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• Porosimeter and BET determination of specific surface Micrometrics model Tristar 3000.
• Accupic 1330 helium pycnometer.

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• PerkinElmer Nexion 350d ICP-MS spectrometer.
• PerkinElmer Nexion 2000 ICP-MS spectrometer.
• PerkinElmer Optima 3200rl simultaneous ICP-OES spectrometer.
• PerkinElmer Optima 8300 simultaneous ICP-OES spectrometer.
• Nu Instruments Plasma 3 multicoIlector ICP-MS spectrometer with Aridus II sample introduction system.
• Panalytical Axios PW 4400/40 sequential wavelength dispersive X-ray spectrometer (WDXRF).
• Milestone DMA-80 direct mercury analyzer.
• Milestone Ultrawave ECR microwave sample digestion system.
• Milestone Ethos One microwave sample digestion system.

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• TRACE gas chromatograph coupled to DSQII mass spectrometer (Thermo Fisher Scientific) with TRIPLUS automatic injector Head Space module
• FocusGC–DSQII gas chromatograph (Thermo Fisher Scientific) with UNITY Series II thermal desorption system(Markes International)
• 6890N gas chromatograph with a 5975 Inert XL mass spectrometer (Agilent Technologies)
• 7890A gas chromatograph with a 5975C Inert XL mass spectrometer (Agilent Technologies). Gerstel autosampler (injectors cis,TDU, HS, PTV)
• 5973 mass spectrometer with a direct introduction probe (Agilent Technologies)
• GC2025 gas chromatograph with a FID detector (Shimadzu)
• TRACE 1300 gas chromatograph with ECD and TCD detectors (ThermoFisher Scientific)
• Cryogenic mill SPEX Certiprep 6850
• Elemental analysers Flash1112 and Flash 2000 (Thermo Scientific) and EA3100 (Eurovector)

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• Combustion tube under an oxygen stream.
• Combustion pump under pressurized oxygen.
• Chemical system for obtaining carbon dioxide by wet basis, acid decomposition or oxidation.
• Chemical system for purifying carbon dioxide.
• Chemical system for reducing carbon dioxide to benzene.
• LKB-Wallac Rackbeta 1217 liquid scintillation counter.
• Packard LL/TL 2255 liquid scintillation counter.

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• ABSciex MALDI TOF/TOF 4800 mass spectrometer.
• Agilent Technologies LC/MSD TOF mass spectrometer coupled to an Agilent 1100 HPLC system.

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• MAT 253 isotope-ratio mass spectrometer (ThermoFisher Scientific) with:
• Kiel IV carbonate device
• Gas Bench system, Precon preconcentrator and Pal automatic sampler
• MAT 253 isotope-ratio mass spectrometer with Kiel III carbonate device
• Delta Plus XP isotope-ratio mass spectrometer (ThermoFisher Scientific) with:
• TC-EA pyrolizer with solid sampler
• TC-EA pyrolizer with liquid sampler
• Carlo Erba 1108 element analyzer
• MAT 253Plus isotope-ratio mass spectrometer (ThermoFisher Scientific) with:
• GC Trace 1310 gas chromatograph with Triplus RSH sampler and GC Isolink II and ConFloIV interfaces
• Gas Bench system, Precon preconcentrator and Pal automatic sampler
• Delta V Advantage isotope-ratio mass spectrometer with a Trace GC gas chromatograph and GCIsolink and ConFlo IV interfaces (ThermoFisher Scientific)
• Delta V Advantage isotope-ratio mass spectrometer with a Flash IRMS element analyzer and a CONFLO IV interface (ThermoFischer Scientific)
• Delta Plus XP (isotope-ratio mass spectrometer (ThermoFisher Scientific) with:
• Agilent 6890 gas chromatograph abd GC Combustion III interfaces
• Surveyor gas chromatograph and LC Isolink interfaces
• Picarro L2130i analyzer with a H₂O stable isotopes HDS-2412 vaporizer

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• Analytik Jena Specord 205 UV-VIS spectrophotometer
• Thermo IN10MX Fourier transform infrared spectrometer with imaging microscope
• Perkin Elmer Frontier Fourier transform infrared spectrometer
• Jasco J-815 spectropolarimeter
• MuSIS 2007 multispectral image analysis system
• Leica DMS300 magnifier

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• LabRam HR800 Raman and photoluminescence microscope.
• Jobin Yvon T64000 Raman high spectral resolution micro/macro with low frequency setting.
• Jobin Yvon VisHead Raman fibre optic analysis system at 785 nm with low frequency setting
• Linkam re-cooling and heating stage (-196 and 600 ºC)
• 5 lasers (325 nm, 514 nm, 532 nm, 785 nm, 1064 nm)
• ULF module to access to ultra-low Raman frequency regions between 5 and 100 cm^-1

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• Bruker ESP300E electron paramagnetic resonance spectrometer.
• Quantum Design MPMS XL SQUID magnetometer.
• Bruker CW/FT-EPR ELEXSYS E580XQ-10/12 pulsed electron paramagnetic resonance spectrometer.

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• Mettler Toledo DSC-822e/400 differential scanning calorimeter
• Mettler Toledo 851e/SF/1100 TGA-SDTA thermobalance
• Microcal VP-ITC isothermal trituration microcalorimeter
• Linkam/Nikon hot-stage thermomicroscope
• Surface Measurement Systems DVS-1000 Dynamic Vapor Sorption

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• Bruker Avance NMR spectrometer 1000 MHz (23.5 Tesla) ultrashielded with cryoprobe.
• Bruker Avance Neo NMR spectrometer (800 MHz) with cryoprobe.
• Bruker Avance III NMR spectrometer (600 MHz) with cryoprobe.
• Varian VNMRS NMR spectrometer (500 MHz).
• 2 Varian Mercury NMR spectrometers (400 MHz).
• Bruker Avance III HD NMR spectrometer (400 MHz) with cryoprobe.
• Bruker Avance Neo NMR spectrometer (500 MHz).
• Bruker Avance Neo NMR spectrometer (400 MHz).

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• TOC|MULTI N/C 3100 element analyser (Analytic Jena)
• Liquid chromatograph:
• Waters 515 HPLC pump
• IC-PAC anion column
• Kontron Waters 432 and UV-VIS conductivity detector
• Crison 522 conductimeter
• Microdrill model MicroMill (Electro Scientific Lasers)

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• Liquid chromatography (HPLC).
• Chromatographic systems Waters 600, Waters Alliance 2695, Waters Alliance 2795 coupled to absorbance detectors (UV-VIS and DAD), fluorescence, refraction index, light dispersion (evaporative), electrochemical and electrical conductivity detectors.
• Agilent HP 1100 chromatograph with DAD detector.
• UHPLC Acquity chromatograph with DAD detector.
• Jasco HPLC 2000 chromatograph with UV-VIS detector and electrical conductivity.
• Biochrom 30 chromatograph with post column derivatization with ninhydrin for the analysis of amino acids.
• Low resolution mass spectrometry coupled with liquid chromatography (HPLC-MS).
• 4000 QTRAP (AB SCIEX) triple quadrupole mass spectrometer coupled to Waters Acquity UPLC chromatograph.
• AB SCIEX 6500 QTRAP triple quadrupole mass spectrometer coupled to Agilent 1290 Infinity UHPLC chromatograph.
• SCIEX 7500 QTRAP triple quadrupole mass spectrometer coupled to Agilent 1290 Infinity II UHPLC.
• High resolution mass spectrometry coupled with liquid chromatography (HPLC-HRMS).
• LTQ-Orbitap Velos (Thermo Fisher Scientific) mass spectrometer equipped with an ion trap and Fourier transform analyzer, coupled to Ultimate 3000 (Thermo Fisher Scientific) UHPLC chromatograph
• QTOF Agilent 6560 mass spectrometer equipped with ionic mobility cell, coupled to Agilent 1290 Infinity II UHPLC chromatograph.
• Orbitrap IQ-X (Thermo Scientific) mass spectrometer equipped with an ion trap, quadrupole and Fourier transform analyzer, coupled to Vanquish Flex (Thermo Scientific) UHPLC chromatograph.

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• Biological irradiator of animals and cells Shepherd Mark I30.
• Hidex model 600 SLe liquid scintillation counters.
• Wallac models 1209 and 1409 liquid scintillation counters.
• Packard models 1500, 2100, 2810 and 2900 liquid scintillation counters.
• Wallac Compugamma solid scintillation gamma counters.
• Packard Cobra II solid scintillation gamma counters.
• Biorad Molecular Imager FX and FX Pro Plus electronic autoradiography units.
• Molecular Dynamics Typhoon 8600 electronic autoradiography unit.
• FAG Contamat FHT-111M surface contamination measuring unit.
• Thermo Scientific (RadEye) NE Technology PDM1A radiation level measuring equipment.
• Atomtex AT1123 X-ray radiation level measuring equipment.
• RTI Electronics Black Piranha,ETR1,Sedentex mannequin, etc. quality control equipment for X-ray units.
• Hewlett Packard Faxitron 43855 A X-ray booth.
• Fuji Medical Film FPM 100A automatic radiographic film developer.
• Rad Elec Inc (Electets E-Perm) radon measurement system equipament in air.
• Specific equipment for the management of radioactive waste and radiological protection.

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• Goratu Group Lagun FU-TV 1250 and Lagun GVM 5-SP universal milling machines equipped with length displays on all three axes and precision accessories .
• Pinacho S-90/225 lathe equipped with display, able to work with diameters of 400 mm.
• Harrison M-300 lathe .
• Metal shears for cutting sheet metal .
• HB320SV drilling saw and saw for flat surfaces .
• Lincoln Electric Invertec V200-T welding equipment .
• Erlo-SPV drill with movable bench .
• Precision and measurement tools.

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