Molecular interaction analysis

• Surface Plasmon Resonance (SPR), real time and label-free interaction analysis.

• Set up for every pair of molecules: optimization of the ligand immobilization (way and density to be immobilized), reference channel, buffer running and temperature.
• Optimization of strategies to obtain the best results in accordance the source of the samples: qualitative or quantitative perspectives.
• Evaluation of the rates constants (kon, koff) and equilibrium constants (KA, KD) in different models: protein/DNA, protein/protein, protein/peptide, carbohydrate/protein, RNA/DNA.
• Selection of active ingredients in pharmacological research.
• Thermodynamic analysis.

• Determination of the binding domain for the analysis of different mutants against targets.
• Effect of cofactors, metal ions and other molecules against the binding kinetics.
• Toxin detection.
• Characterization of immune response.
• Effect (in kinetics terms) of different modifications of antibodies.

Surname	Name	Location	Phone number	Email
TAULÉS MARIN (*)	MARTA	Edifici Clúster (PCB) C/ Baldiri Reixac, 10	934037200	marta@ccit.ub.edu

      (*) for more information