Noticias16.09.2015Publicación del artículo "Two New Polymorphic Cocrystals of Zafirlukast: Preparation, Crystal Structure, and Stability Relations" |
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El Dr. Rafel Prohens, responsable de la Tecnología de Polimorfismo y Calorimetría, junto con el Dr. Rafael Barbas, de la misma tecnología y la Dra. Mercè Font-Bardia, de la Tecnología de Difracción de Rayos X, han publicado el artículo "Two New Polymorphic Cocrystals of Zafirlukast: Preparation, Crystal Structure, and Stability Relations" en la revista Crystal Growth & Design. Esta revista es una de las de mayor impacto de la química de estado sólido y el artículo en cuestión se puede consultar en el siguiente link [+].
Resumen del artículo: "Two new cocrystals of zafirlukast with piperazine, existing in five different solid forms, have been discovered during a cocrystal screening. The crystal structure of one of these forms has been determined by single crystal X-ray diffraction, and the stability landscape of the crystalline forms of the new cocrystal has been studied. In the present article, we extend the knowledge about the solid state of this important pharmaceutical drug for the treatment of asthma by reporting the crystal structures of two new solvates (acetonitrile and butanol) and the elusive anhydrous Form X, which have been solved by single crystal X-ray diffraction.” | |