Centres Científics i Tecnològics UB

News

16.09.2015

Publication of the paper "Two New Polymorphic Cocrystals of Zafirlukast: Preparation, Crystal Structure, and Stability Relations"

PhD. Rafel Prohens, responsible of the Polymorphism and Calorimetry Technology of the CCiTUB, along with PhD. Rafael Barbas, of the same technology, and PhD. Mercè Font-Bardia, of the X-Ray Diffraction Technology of the CCiTUB, have published the article "Two New Polymorphic cocrystals of Zafirlukast: Preparation, Crystal Structure, and Stability Relations "in the journal Crystal Growth & Design. This is one of the solid state chemistry magazines with a higher impact and the article in question is available at the following link [+] .

Article Summary:

"Two new cocrystals of zafirlukast with piperazine, existing in five different solid forms, have been discovered during a cocrystal screening. The crystal structure of one of these forms has been determined by single crystal X-ray diffraction, and the stability landscape of the crystalline forms of the new cocrystal has been studied. In the present article, we extend the knowledge about the solid state of this important pharmaceutical drug for the treatment of asthma by reporting the crystal structures of two new solvates (acetonitrile and butanol) and the elusive anhydrous Form X, which have been solved by single crystal X-ray diffraction.”