Noticias11.02.2015Publicación del artículo "Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil" |
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Los técnicos de los CCiTUB Rafel Prohens, Rafael Barbas, Anna Portell y Cristina Puigjaner, de la Tecnología de Polimorfismo y Calorimetría, conjuntamente con Mercè Font-Bardia y Xavier Alcobé, de la Tecnología de Difracción de Rayos X, han publicado el artículo " Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil" en la revista Crystal Growth & Design.
El abstract del artículo es el siguiente: "The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single crystal X-ray diffraction." El artículo completo se puede leer en el siguiente enlace [+] | |