News11.02.2015Publication of the paper "Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil" |
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The technicians of the CCiTUB Rafel Prohens, Rafael Barbas, Anna Portell and Cristina Puigjaner, of the Polimorphism and Calorimetry Technology, together with Mercè Font-Bardia and Xavier Alcobé, of the X-Ray Diffraction Technology, have published the paper "Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil" in the journal Crystal Growth & Design.
The abstract of the paper is the following: "The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single crystal X-ray diffraction." You can read the complete paper in the next link [+] | |