Centres Científics i Tecnològics UB

Noticias

24.02.2016

Publicación del artículo “Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector”

El Dr. Joaquim Portillo, responsable de la Tecnología de MET Aplicada a Materiales de los CCiTUB, ha participado en el artículo “Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector”, en el cual se ha utilizado el detector Timepix de la empresa Nanomegas.
Dicho artículo ha sido publicado recientemente en la revista Acta Crystallographica A, y puede ser consultado en el siguiente link [+].

El abstract del artículo es:

“Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enabling ab initio phasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS, SHELX) and for electron crystallography (ADT3D/PETS, SIR2014).”