Notícies

24.02.2016

Publicació de l'article “Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector”

El Dr. Joaquim Portillo, responsable de la Tecnologia de MET Aplicada a Materials dels CCiTUB, ha participat en l'article “Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector”, en el qual s'ha utilitzat el detector Timepix de l'empresa Nanomegas.
Aquest article ha estat publicat recentment a la revista Acta Crystallographica A, i pot ser consultat en el següent link [+].

L'abstract de l'article és:

“Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enabling ab initio phasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS, SHELX) and for electron crystallography (ADT3D/PETS, SIR2014).”