Notícies
15.06.2020Publicació de l'article "Morphotropism and 'Quasi-Isostructurality' in the Three High Z′ Concomitant Polymorphs of Efinaconazole”
El Dr. Rafel Prohens, responsable de la Tecnologia de Polimorfisme i Calorimetria dels CCiTUB, juntament amb el Dr. Rafael Barbas de la mateixa unitat i la Dra. Mercè Font-Bardia de la Tecnologia de Difracció de Raigs X dels CCiTUB, han publicat l'article "Morphotropism and ‘Quasi-Isostructurality’ in the Three High Z′ Concomitant Polymorphs of Efinaconazole" a la revista Crystal Growth & Design.
El resum de l'article és el següent:
"The crystal structures of the three efinaconazole anhydrous forms have been solved by single-crystal X-ray diffraction showing a very rare case of nearly isostructural polymorphism. The analysis of their crystal structures revealed that forms I and III are 'quasi-isostructural' polymorphs and are morphotropically related to form II. The identical conformational and supramolecular environment can explain the concomitant polymorphism phenomenon observed for this important active pharmaceutical ingredient."
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