Noticias26.06.2018Publicación de artículos relacionados con la cirugía bariátrica |
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Recientemente, la Dra. Olga Jáuregui, miembro de la unidad de Técnicas Separativas de los CCiTUB, ha participado en la publicación de dos estudios relacionados con la cirugía bariátrica que tratan la pérdida de peso. El artículo “Characterization of metabolomic profile associated with metabolic improvement after bariatric surgery in subjects with morbid obesity” fue publicado en la revista científica Journal of Proteome Research impulsada por la American Chemical Society (ACS) de los Estados Unidos el 12 de Junio y su resumen es el siguiente: “The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF -MS- driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3 and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses were carried out to distinguish those metabolites associated with metabolic improvement. Hydroxy-propionic acids, medium-/long-chain hydroxy-fatty acids and bile acid -glucuronides were the most discriminative biomarkers of response between MH and MU phenotypes. Hydroxy-propionic (hydroxyphenyllactic-related) acids, amino acids and glycerolipids were the most significant clusters of metabolites altered after bariatric surgery in MU (p<0.001). MU and MH changes after surgery towards a common metabolic state already 3 months after surgery. We observed a negative correlation with changes in waist circumference and cholesterol levels with metabolites of lipid metabolism. Glycaemic variables were correlated with hexoses, which, in turn, correlated with gluconic acid and amino acid metabolism. Finally, we noted that hydroxyphenyllactic acid was associated with amino acid and lipid metabolism. Microbial metabolism of amino acid and BA glucuronidation pathways may be the key points of metabolic rearranges after surgery.” El segundo artículo titulado “Metabotypes of response to bariatric surgery independent of the magnitude of weight loss” fue publicado en la revista científica americana PLOS One el 1 de junio. El resumen se muestra a continuación: “OBJECTIVE: Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations. METHODS: We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery. RESULTS: For the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss. CONCLUSIONS: This study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases.” |
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