News22.02.2018Uses of cytometry for the study of colon cancer |
|
|
The Citometry Technology of the Centres Científics i Tecnológics de la UB has participated in the analysis of the samples used in the paper “TGFβ drives immune evasion in genetically reconstituted colon cancer metástasis”, published at Nature journal. Tumor development and metastasis formation is a complex process with different type of cells involved. The paper published in Nature journal explains the way colon tumours are often unresponsive to immunotherapy (stimulate immunologic system against cancer cells), and to identify the molecule (TGF-beta hormone) responsible of the lack of response of the immune system to the colon cancer cells. Eduard Batlle, Daniele V.F. Tauriello and the other researchers who sign this paper have been using the services provided in the cytometry unit of the CCiTUB mainly for: -identifying tumour populations with a specific immunoprofile by flow cytometry, using multiple immunofluorescence techniques, and detect the changes in the cells related to immunotherapy treatments. -purification (sorting) of tumour cells with a specific profile, to use them in different applications. Flow cytometry of the Citometry Technology of the Centres Científics i Tecnológics de la UB is a tool able to analyze complex situations and detect specific cell populations present even at very low frequencies due to its capability to detect multiple parameters on each cell combined with a high speed of measurement. |
|