Centres Científics i Tecnològics UB

News

15.11.2021

Publication of the paper "The Solid State Landscape of the Sildenafil Drug"

PhD. Rafel Prohens, responsible of the Polymorphism and Calorimetry Unit of the CCiTUB, along with PhD. Rafael Barbas, a same unit technician, in collaboration with the Swedish pharmaceutical company Astrazeneca, has published the paper "The Solid State Landscape of the Sildenafil Drug" in the "European Journal of Pharmaceutical Sciences."

The summary of the article is:

"Sildenafil, the active ingredient of the drug developed by Pfizer for the treatment of erectile dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has become one of the most prescribed drugs for sexual performance in the western world with more than 2.7 million prescriptions in the US in 2021. Since its discovery, this drug compound has attracted the interest of formulators and crystallographers, with a high number of crystal forms of sildenafil being found and characterized, including polymorphs, hydrates, solvates, salts and cocrystals, converting it in one of the most promiscuous multicomponent crystal former drugs in the pharmaceutical sciences arena. In this minireview, the polymorph, pseudopolymorph and multicomponent solid forms landscape of sildenafil is presented through a comprehensive compilation of their 42 solid forms reported in literature."