News18.06.2018Publication of the article “Polymorphism of Sildenafil: A new metastable desolvate” |
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PhD. Rafel Prohens, Responsible of the Polymorphism and Calorimetry Technology of the CCiTUB, along with Mr. Rafael Barbas technician of the same technology, and PhD. Mercè Font technician of the X-Ray Diffraction technology, have published the article:“Polymorphism of Sildenafil: A new metastable desolvate” in the journal Crystal Growth & Design published on June 12th. The article has been made possible thanks to the collaboration University-Company, in this particular case, in the framework of the agreement between the company CIRCE Crystal Engineering and the CCiTUB. The summary of the article is: "A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of Active Pharmaceutical Ingredients." More information about the article in question is available at the following link: [+]. |
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